• 19057

Prof. Dr. Ahmed Sayed

    Head of Genomics and Epigenomics Research Program

Head of Genomics and Epigenomics Research Program


Education:

  • PhD. in Molecular Biology & Genetics, Faculty of Science, University of Illinois USA.
  • MSc. in Biochemistry & Endocrinology, Faculty of Science, University of Ain Shams.
  • BSc. in Biochemistry, Faculty of Science, University of Ain Shams.

Publications:

https://scholar.google.com/citations?user=XTzxEX0AAAAJ&hl=en
  • AlShaimaa Taha, Ahmed Sayed, Ahmed Salem, Salah Diab, omayma Eldahshan. (2019). Modulatory Effect of Prosopis juliflora Leaves on Hepatic Fibrogenic and Fibrolytic Alterations Induced in Rats by Thioacetamide. Biomedicine & Pharmacotherapy.
  • El-Din, M. S., Taha, A. M., Sayed, A. A., & Salem, A. M. (2019). Ziziphus spina-christi leaves methanolic extract alleviates diethylnitrosamine-induced hepatocellular carcinoma in rats. Biochemistry and cell biology.
  • Elham A. Badiea, Mahmoud M. Said, Mohamad Maged, Walid M. Fouad, Ahmed A. Sayed, Amr Y. Esmat (2019) A novel thermostable halophilic thioredoxin reductase from Red Sea brine pool. Scientific reports (submitted).
  • Mai Khalil, Ahmed Sayed and Justin Grubich. (2016) Biochemical characterization of venom protein of Red Sea Lionfish (Pterois miles) and evaluation of its anti-cancer activity. Egyptian Journal of Pure and Applied Science.
  • Mohamed A. Ghazy and Ahmed A. Sayed. (2015) Fast and Reproducible PCR-Based Approach for DNA Library Screening. Egyptian Journal of Pure and Applied Science.
  • Rehab Z Abdallah, Mustafa Adel, Amged Ouf, Ahmed Sayed, Mohamed Ghazy, Intikhab Alam, Magbubah Essack, Feras F. Lafi, Vladimir B. Bajic, Hamza El-Dorry and Rania Siam. (2014) Differential Aerobic Methanotrophic Communities in Red Sea Brine-Seawater Interfaces. Frontiers in Microbiology.
  • J.S Ferreira, R. Siam, A. Sayed, M. Ghazy, A. Dawe, A. Ouf, F. Chambergo, J. C. Setubal, E. Ramadan, A. Antunes, U. Sting, I. Alam, J. A. C. Archer, B. Jankovic,2 V. Bijic, H.El-Dorry. (2014) Core Microbial Functional Activities in Ocean Environments Revealed by Global Metagenomic Profiling Analyses. PLoS ONE 9:6-e97338.
  • Ahmed Sayed, Mohamed Ghazy, Ari J.S. Ferreira, Amged Ouf, Archer, Mustafa Adel, Felipe S. Chambergo, Adam Dawe, John A.C., Vladimir Bajic, Rania Siam, and Hamza El-Dorry. (2014) A novel mercuric reductase from the unique deep brine environment. Journal of Biological Chemistry 289: 1675-1687.
  • Ahmed M. Salem, Hala T. El-Bassyouni, Ghada Y. El-Kamah, Waheba A. Zarouk, Maha M. Eid, Rehab M. Mosaad, Ahmed A. Sayed and Samia A. Temtamy.(2014) Screening for common mutations in four FANCA gene exons in Egyptian Fanconi anemia patients. Middle East Journal of Medical Genetics. 3:24–30.
  • Ashraf A. Tabll, Khaled Atef, Noha G. Bader El Din, Yasmine S. El Abd, Ahmed Salem, Ahmed A. Sayed, Reham M. Dawood, Moataza H. Omran, and Mostafa K. El-Awady. (2014) in vitro neutralization of hcv by goat antibodies against peptides encompassing regions downstream of HVR-1 of E2 glycoprotein. Journal of Immunoassay and Immunochemistry, 35:12–25.
  • Ahmed M.Salem, Samira Ismail, Waheba A. Zarouk, Olwya Abdul Baky, Ahmed A. Sayed, Sawsan Abd El-Hamid, and Sohair Salem. (2013) Genetic Variants of Neurotransmitter-Related Genes and miRNAs in Egyptian Autistic Patients. The Scientific World Journal 2013: 670621.
  • Yasmine M. Mohamed, Mohamed A. Ghazy, Ahmed Sayed, Amged Ouf, Hamza El-Dorry & Rania Siam. (2013) Isolation and characterization of a heavy metal-resistant, thermophilic esterase from a Red Sea Brine Pool. SCIENTIFIC REPORTS 3: 3358.
  • Angelucci, F., Sayed, A.A.v, Williams, D.L., Boumis, G., Brunori, M., Dimastrogiovanni, D., Miele, A.E., Pauly F. Bellelli, A. (2009) Inhibition of Schistosoma mansoni thioredoxin glutathione reductase by auranofin: structural and kinetic aspects. Journal of Biological Chemistry 284, 28977-28985.
  • Rai G, Sayed AA, Lea W, Luecke H, Chakrapani H, Prast-Nielsen S, Jadhav A,Leister W, Shen M, Inglese J, Austin CP, Keefer L, Arnér ESJ, Simeonov A,Maloney DJ, Williams DL, Thomas CJ. (2009) Structure-mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. Journal of Medicinal Chemistry 52, 6474-6483.
  • Knight, M., Raghavan, N., Goodall, C., Cousin, C., Ittipraserta, W., Sayed, A., Miller, A., Williams, D.L., Bayne, C.J. (2009) Biomphalaria glabrata peroxiredoxin: Effect of Schistosoma mansoni infection on differential gene regulation. Molecular and Biochemical Parasitology 167, 20-31.
  • Sheila Donnelly, Colin M. Stack, Sandra M. O’Neill, Ahmed A. Sayed,David L. Williams, and John P. Dalton. Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated Macrophages. The FASEB Journal fj.08-106278. August 15, 2008.
  • Ahmed A. Sayed, Anton Simeonov, Craig J. Thomas, James Inglese, Christopher P. Austin, David L. Williams. Identification of Oxadiazoles as New Drug Leads for the Control of Schistosomiasis. Nature Medicine 14, 407-412, 2008.
  • Wendy A. Lea, Ajit Jadhav, Ganesha Rai, Ahmed A. Sayed, Cynthia L. Cass, James Inglese, David L. Williams, Christopher P. Austin, and Anton Simeonov. A 1,536-Well-Based Kinetic HTS Assay for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase. ASSAY and Drug Development Technologies Volume 6, Number 4, 2008.
  • Simeonov, A., Jadhav, A., Sayed, A.A., Wang, Y., Nelson, M.E., Thomas, C.J., Inglese, J., Williams, D.L., Austin, C.P. Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade. PLoS Neglected Tropical Diseases Dis 2(1): e127, 2008.
  • Williams, D.L., Sayed, A.A., Bernier, J., Birkeland, S.R., Cipriano, M.J., Papa, A.R., McArthur, A.G., Taft, A., Vermeire, J.J., Yoshino, T.P. (2007) Profiling Schistosoma mansoni development using Serial Analysis of Gene Expression (SAGE). Experimental Parasitology 117, 246–258.
  • Kuntz, A.N., Davioud-Charvet, E., Sayed, A.A., Califf, L.L., Dessolin, J., Arnér, E.S.J., Williams, D.L. (2007) Thioredoxin glutathione reductase from Schistosoma mansoni: An essential parasite enzyme and a key drug target. PLoS Medicine 4(6), e206.
  • Williams, D.L., Sayed, A.A., Ray, D., and McArthur A.G. (2006) Schistosoma mansoni albumin, a major defense against oxidative damage, was acquired by lateral gene transfer from a mammalian host. Molecular and Biochemical Parasitology 150, 359–363.
  • Sayed, A.A., Cook S.K., and Williams D.L. (2006) Redox balance mechanisms in Schistosoma mansoni rely on peroxiredoxins and albumin and implicate peroxiredoxins as novel drug targets. Journal of Biological Chemistry 281, 17001-17010.
  • Sayed, A. A., D. L. Williams (2004) Biochemical characterization of 2-Cys peroxiredoxins from Schistosoma mansoni. Journal of Biological Chemistry 279, 26159-26166.
  • Alger, H. M., A. A. Sayed, M. J. Stadecker, D. L. Williams (2002) Molecular and enzymatic characterization of Schistosoma mansoni thioredoxin. International Journal for Parasitology 32:1285-1292