Continued">Continued">Continued">What do we need to know about BMT – Children Cancer Hospital Egypt 57357
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Bone Marrow Transplant Unit

What do we need to know about BMT

  • A bone marrow transplant is a procedure that infuses healthy blood-forming stem cells into your body to replace your damaged or diseased bone marrow.
  • The spongy tissue inside the bone (bone marrow) contains stem cells.
    • Stem cells are ‘mother’ cells that change and evolve to become other blood cells.
    • A stem cell divides into more cells, and throughout this process, its ‘daughter cells’ will be differentiated into various blood cells, e.g., red blood cells, white blood cells, and platelets.
  • You might need a bone marrow transplant if your bone marrow stops working and does not produce enough healthy blood cells.
  • Bone marrow transplants may use cells from your own body (autologous transplant) or a healthy related or unrelated donor (allogeneic transplant).

A bone marrow transplant may be used to:

  • Safely allow treatment of your condition with high doses of chemotherapy or radiation by replacing or rescuing the bone marrow damaged by treatment. Replace diseased or damaged marrow with new stem cells.
  • Provide new stem cells, which can help kill cancer cells directly.

  • Autologous transplant
  • Allogeneic transplant
  • Autologous SCT indications
    • Relapsed Non-Hodgkin Disease
    • Relapsed/refractory Hodgkin's Disease
    • High-risk neuroblastoma
    • High risk and infantile Medulloblastoma
    • Extra ocular Retinoblastoma
    • Relapsed Wilms Tumor, Ewing Sarcoma & Germ cell tumor
  • Allogeneic HSCT indications
MalignantBenign disorders

Leukemia

  1. Acute myeloid leukemia
  2. Acute lymphoblastic leukemia
  3. Chronic myeloid leukemia
  4. Juvenile Myelomonocytic Leukemia

Lymphoma

  1. Relapsed Non-Hodgkin Disease
  2. Relapsed Hodgkin Disease

  • Hemoglobinopathies
  • Immune deficiencies
  • Congenital Bone marrow failure
  • Inborn errors of metabolism
  • Aplastic anemia
  • Osteopetrosis
  • For many people who have leukemia, lymphoma, or certain other blood disorders, BMT offers the best chance of a cure.
  • But only about 25% of people who need an allogeneic transplant — the type of transplant in which donor cells are used — have a sibling who is a suitable genetic match.
  • The remaining 75% usually look to registries of unrelated volunteers to find a compatible donor.