The Proteomics and Metabolomics Program

• Amer, N., Hesham, D., Al-Shehaby, N., Elshoky, H. A., Amer, M., Magdeldin, S., Mansour, M., Abou-Aisha, K., & El-Naggar, S. LC3A-mediated autophagy elicits PERK-eIF2α-ATF4 axis activation and mitochondrial dysfunction: Exposing vulnerability in aggresome positive cancer cells. Journal of Biological Chemistry.


• Mahdally NH, ElShiekh RA, Thissera B, Eltaher A, Osama A, Mokhtar M, Elhosseiny NM, Kashef MT, Magdeldin S, El Halawany AM, Rateb ME, Attia AS. Dihydrophenazine: a multifunctional new weapon that kills multidrug-resistant Acinetobacter baumannii and restores carbapenem and oxidative stress susceptibilities. J Appl Microbiol. 2024 May 1;135(5): lxae100.
  PMID: 38627251


• El Awady ME, Mohamed SS, Abo Elsoud MM, Mahmoud MG, Anwar MM, Ahmed MM, Eltaher A, Magdeldin S, Attallah A, Elhagry AE, Abdelhamid SA. Insight into antioxidant and anti-inflammatory effects of marine bacterial natural exopolysaccharide (EPSSM) using carrageenan-induced paw edema in rats. Sci Rep. 2024 Mar 1;14(1): 5113.
  PMID: 38429312


• Ahmed, T. A., Ahmed, S. M., Elkhenany, H., El-Desouky, M. A., Magdeldin, S., Osama, A., Anwar, A. M., Mohamed, I. K., Abdelgawad, M. E., Hanna, D. H., & El-Badri, N. (2024). The cross talk between type II diabetic microenvironment and the regenerative capacities of human adipose tissue-derived pericytes: a promising cell therapy. Stem cell research & therapy, 15(1), 36.
  PMID: 38331889


• Hesham, D., On, J., Alshahaby, N., Amer, N., Magdeldin, S., Okada, M., Tsukamoto, Y., Hiraishi, T., Imai, C., Okuda, S., Wakai, T., Kakita, A., Oishi, M., El-Naggar, S., & Natsumeda, M. (2024). Multi-omics analyses of choroid plexus carcinoma cell lines reveal potential targetable pathways and alterations. Journal of neuro-oncology, 10.1007/s11060-023-04484-3.
  PMID: 38190092


• Alaa, M., Al-Shehaby, N., Anwar, A. M., Farid, N., Shawky, M. S., Zamzam, M., Zaky, I., Elghounimy, A., El-Naggar, S., & Magdeldin, S. (2023). Comparative Shotgun Proteomics Reveals the Characteristic Protein Signature of Osteosarcoma Subtypes. Cells, 12(17), 2179.
  PMID: 37681913


• Moglad, E., Elekhnawy, E., Negm, W. A., Mokhtar, F. A., Binsuwaidan, R., Attallah, N. G. M., Ahmed, E., Magdeldin, S., & Al-Fakhrany, O. M. (2023). Evaluation of Tamarix nilotica Fractions in Combating Candida albicans Infections. Expert review of anti-infective therapy, 1–11.
  PMID: 37387417


• Rady, A. M., El-Sayed, A. S. A., El-Baz, A. F., Abdel-Fattah, G. G., Magdeldin, S., Ahmed, E., Osama, A., Hassanein, S. E., Saed, H., & Yassin, M. (2023). Proteomics and metabolomics analyses of camptothecin-producing Aspergillus terreus reveal the integration of PH domain-containing proteins and peptidylprolyl cis/trans isomerase in restoring the camptothecin biosynthesis. Microbiology spectrum, e0228123.
  PMID: 37855596


• Assiri, R. A., El-Masry, T. A., El-Haggar, S. M., Elekhnawy, E., Eldin, S. S., El-Kadem, A. H., Mostafa, S. A., Elberri, A. I., Magdeldin, S., Negm, W. A., & Mokhtar, F. A. (2023). Phytochemical investigation, antibacterial, and ameliorative potential effects of Tamarix nilotica on LPS-induced acute lung injury model in mice. Biomedicine & pharmacotherapy. 168, 115678.
  PMID: 37820564


• Ezzeldin, S., Osama, A., Anwar, A.M., Mahgoub, S., Ahmed, E.A., Farid, N., Zamzam, M., El Ghoneimy, A. and Magdeldin, S., 2023. Detection of early prognostic biomarkers for metastasis of Ewing's sarcoma in pediatric patients. Life Sciences, p.122237.
  PMID: 37926299


• Saleh, A., Negm, W. A., El-Masry, T. A., Eliwa, D., Alotaibi, B., Alosaimi, M. E., Alotaibi, K. N., Magdeldin, S., Mahgoub, S., & Elekhnawy, E. Anti-inflammatory potential of Penicillium brefeldianum endophytic fungus supported with phytochemical profiling. Microbial cell factories, 2023, 22(1), 83.
  PMID: 37106372


• Binsuwaidan, R.; Negm, W.A.; Elekhnawy, E.; Attallah, N.G.M.; Ahmed, E.; Magdeldin, S.; Moglad, E.; Mostafa, S.A.; El-Sherbeni, S.A. In Vitro Antiviral Effect and Potential Neuroprotection of Salvadora persica L. Stem Bark Extract against Lipopolysaccharides-Induced Neuroinflammation in Mice: LC-ESI-MS/MS Analysis of the Methanol Extract. Pharmaceuticals 2023, 16, 398.
  PMID: 36986497


• Sameh, M., Khalaf, H. M., Anwar, A. M., Osama, A., Ahmed, E. A., Mahgoub, S., Ezzeldin, S., Tanios, A., Alfishawy, M., Said, A. F., Mohamed, M. S., Sayed, A. A., & Magdeldin, S. (2023). Integrated multiomics analysis to infer COVID-19 biological insights. Scientific reports, 13(1), 1802.
  PMID: 36720931


• Ahmed, E. A., El-Derany, M. O., Anwar, A. M., Saied, E. M., & Magdeldin, S. (2022). Metabolomics and Lipidomics Screening Reveal Reprogrammed Signaling Pathways toward Cancer Development in Non-Alcoholic Steatohepatitis. International journal of molecular sciences, 24(1), 210.
  PMID: 36613653


• Hegazy, M. M., Afifi, W. M., Metwaly, A. M., Radwan, M. M., Abd-Elraouf, M., Mehany, A. B. M., Ahmed, E., Enany, S., Ezzeldin, S., Ibrahim, A. E., El Deeb, S., & Mostafa, A. E. (2022). Antitrypanosomal, Antitopoisomerase-I, and Cytotoxic Biological Evaluation of Some African Plants Belonging to Crassulaceae; Chemical Profiling of Extract Using UHPLC/QTOF-MS/MS. Molecules, 27(24), 8809.
  PMID: 36557948


• Ezzat, A. A., Tammam, S. N., Hanafi, R. S., Rashad, O., Osama, A., Abdelnaby, E., Magdeldin, S., & Mansour, S. “Different Serum, Different Protein Corona! The Impact of the Serum Source on Cellular Targeting of Folic Acid-Modified Chitosan-Based Nanoparticles”. Molecular pharmaceutics (2022).
  PMID: 35380849


• Hussein, M.A., Hussein, H.A., Thabet, A.A., Selim, K.M., Dawood, M.A., El-Adly, A.M., Wardany, A.A., Sobhy, A., Magdeldin, S., Osama, A., Anwar, A., et.al. “Human Wharton’s Jelly Mesenchymal Stem Cells Secretome Inhibits Human SARS-CoV-2 and Avian Infectious Bronchitis Coronaviruses”. Cells (2022).
  PMID: 35563714


• Attallah, N. G., Mokhtar, F. A., Elekhnawy, E., Heneidy, S. Z., Ahmed, E., Magdeldin, S., ... & El-Kadem, A. H. “Mechanistic Insights on the In Vitro Antibacterial Activity and In Vivo Hepatoprotective Effects of Salvinia auriculata Aubl against Methotrexate-Induced Liver Injury”. Pharmaceuticals (2022).
  PMID: 35631375


• Zerfaoui, M., Tsumagari, K., Toraih, E., Errami, Y., Ruiz, E., Elaasar, M.S.M., Krzysztof, M., Sholl, A.B., Magdeldin, S., Soudy, M. and Abd Elmageed, Z.Y. “Nuclear interaction of Arp2/3 complex and BRAFV600E promotes aggressive behavior and vemurafenib resistance of thyroid cancer”. American journal of cancer research (2022).
  PMID: 35968344


• Magdeldin, S., et.al. “The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019”. Lancet. (2022).
  PMID: 35988567


• Shikshaky, H., Ahmed, E. A., Anwar, A. M., Osama, A., Ezzeldin, S., Nasr, A., Mahgoub, S., & Magdeldin, S. “A Novel Approach of SWATH-Based Metabolomics Analysis Using the Human Metabolome Database Spectral Library. International journal of molecular sciences (2022).
  PMID: 36142821


• Binsuwaidan, R., Elekhnawy, E., Elseady, W. S., Keshk, W. A., Shoeib, N. A., Attallah, N. G. M., Mokhtar, F. A., Abd El Hadi, S. R., Ahmed, E., Magdeldin, S., & Negm, W. A. “Antibacterial activity and wound healing potential of Cycas thouarsii R.Br n-butanol fraction in diabetic rats supported with phytochemical profiling”. Biomedicine & pharmacotherapy (2022).
  PMID: 36182739


• Elnaggar, A., Osama, A., Anwar, A. M., Ezzeldin, S., Abou Elhassan, S., Ebeid, H., ... & Magdeldin, S. “Paleoproteomic profiling for identification of animal skin species in ancient Egyptian archaeological leather using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)”. Heritage Science (2022).


• Salah, R.A., Nasr, M.A., El-Derby, A.M., Abd Elkodous, M., Mohamed, R.H., El-Ekiaby, N., Osama, A., Elshenawy, S.E., Hamad, M.H.M., Magdeldin, S. and Gabr, M.M. “Hepatocellular carcinoma cell line-microenvironment induced cancer-associated phenotype, genotype and functionality in mesenchymal stem cells”. Life Sciences (2022).
  PMID: 34826437


• Amer, N., Taha, H., Hesham, D., Al-Shehaby, N., Mosaab, A., Soudy, M., Osama, A., Mahmoud, N., Elayadi, M., Youssef, A. and Elbeltagy, M., et al. “Aggresomes predict poor outcomes and implicate proteostasis in the pathogenesis of pediatric choroid plexus tumors”. Journal of neuro-oncology (2021).
  PMID: 33501605


• Nafie, Mohamed S., Safaa M. Kishk, Sebaey Mahgoub, and Atef M. Amer. "Quinoline‐based thiazolidinone derivatives as potent cytotoxic and apoptosis‐inducing agents through EGFR inhibition." Chemical Biology & Drug Design (2021).
  PMID: 34873844


• Anwar AM, Ahmed EA, Soudy M, Osama A, Ezzeldin S, Tanios A, Mahgoub S, Magdeldin S. Xconnector: Retrieving and visualizing metabolites and pathways information from various database resources. J Proteomics (2021).
  PMID: 34111608


• Qunaibi E, Basheti I, Soudy M, Sultan I. Hesitancy of Arab Healthcare Workers towards COVID-19 Vaccination: A Large-Scale Multinational Study. Vaccines (Basel) (2021).
  PMID: 34063313


• Mohammed, Hamdoon A., et al. "Phytochemical Profiling, In Vitro and In Silico Anti-Microbial and Anti-Cancer Activity Evaluations and Staph GyraseB and h-TOP-IIβ Receptor-Docking Studies of Major Constituents of Zygophyllum coccineum L. Aqueous-Ethanolic Extract and Its Subsequent Fractions: An Approach to Validate Traditional Phytomedicinal Knowledge." Molecules (2021). PMID: 33499325


• Nafie MS, Mahgoub S, Amer AM. Antimicrobial and antiproliferative activities of novel synthesized 6-(quinolin-2-ylthio) pyridine derivatives with molecular docking study as multi-targeted JAK2/STAT3 inhibitors. Chem Biol Drug Des. (2021).
  PMID: 32920942


• Ashour ME, Allam W, Elsayed W, Atteya R, Elserafy M, Magdeldin S, Hassan MK, El-Khamisy SF. High Temperature Drives Topoisomerase Mediated Chromosomal Break Repair Pathway Choice. Cancers (Basel) (2021).
  PMID: 34065967


• Hegazy, Mostafa M., et al. "Biological and chemical evaluation of some African plants belonging to Kalanchoe species: Antitrypanosomal, cytotoxic, antitopoisomerase I activities and chemical profiling using ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometer." Pharmacognosy Magazine (2021).
  DOI: 10.4103/pm.pm_232_20


• Ezzeldin, Shahd, Aya El-Wazir, Shymaa Enany, Abdelrahman Muhammad, Dina Johar, Aya Osama, Eman Ahmed, Hassan Shikshaky, and Sameh Magdeldin.
  "Current Understanding of Human Metaproteome Association and Modulation." Journal of proteome research (2019).
  PMID: 27535355


• Soudy M, Anwar AM, Ahmed EA, et al. UniprotR: Retrieving and visualizing protein sequence and functional information from Universal Protein Resource (UniProt knowledgebase). J Proteomics. 2020.
  PMID: 31843688


• Saadeldin IM, Swelum AA, Elsafadi M, Magdeldin S, et al. Thermotolerance and plasticity of camel somatic cells exposed to acute and chronic heat stress. J Adv Res. 2019.
  PMID: 31969994


• Burstein R, Henry NJ, Collison ML, Magdeldin S, et al. Mapping 123 million neonatal, infant and child deaths between 2000 and 2017. Nature. 2019.
  PMID: 31619795


• Morsi M, Kobeissy F, Magdeldin S, et al. A shared comparison of diabetes mellitus and neurodegenerative disorders. J Cell Biochem. 2019.
  PMID: 28681964


• El-Gammal, Zaynab, et al. "Human-stimulated oocyte extract induces genetic and mitochondrial reprogramming of mesenchymal stromal cells." Plos one 15.5 (2020): e0232759.
  PMID: 32453737


• Reiner Jr, Robert C., et al. "Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017." The Lancet (2020).
  PMID: 32513411


• Enany, Shymaa, et al. "Shotgun proteomic analysis of ESBL-producing and non-ESBL-producing Klebsiella Pneumoniae clinical isolates." Microbiological Research 234 (2020): 126423.
  PMID: 32078895

https://scholar.google.com/citations?user=EnP_f8UAAAAJ

• Elguoshy, A., Magdeldin, S., Xu, B., Hirao, Y., Zhang, Y., Kinoshita, N., Takisawa, Y., Nameta, M., Yamamoto, K., El-Refy, A., El-Fiky, F., Yamamoto, T., 2016. Why are they missing? : Bioinformatics characterization of missing human proteins. Journal of proteomics 149, 7-14.
  PMID: 27535355


• Magdeldin, S., Hirao, Y., El Guoshy, A., Xu, B., Zhang, Y., Fujinaka, H., Yamamoto, K., Yates, J.R., 3rd, Yamamoto, T., 2016a. Comprehensive data analysis of human ureter proteome. Data in brief 6, 853-857.
  PMID: 27535355


• Magdeldin, S., Hirao, Y., Elguoshy, A., Xu, B., Zhang, Y., Fujinaka, H., Yamamoto, K., Yates, J.R., 3rd, Yamamoto, T., 2016b. A proteomic glimpse into human ureter proteome. Proteomics 16, 80-84.
  PMID: 26442468


• Yaoita, E., Nishimura, H., Nameta, M., Yoshida, Y., Takimoto, H., Fujinaka, H., Kawachi, H., Magdeldin, S., Zhang, Y., Xu, B., Oyama, T., Nakamura, F., Yamamoto, T., 2016. Avian Podocytes, Which Lack Nephrin, Use Adherens Junction Proteins at Intercellular Junctions. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 64, 67-76.
  PMID: 26416242


• Zhang, Y., Xu, B., Kinoshita, N., Yoshida, Y., Tasaki, M., Fujinaka, H., Magdeldin, S., Yaoita, E., Yamamoto, T., 2015b. Datasets from label-free quantitative proteomic analysis of human glomeruli with sclerotic lesions. Data in brief 4, 180-185.
  PMID: 26217785


• Magdeldin, S., Elguoshy, A., Yoshida, Y., Hirao, Y., Xu, B., Zhang, Y., Yamamoto, K., Takimoto, H., Fujinaka, H., Kinoshita, N., Yamamoto, T., 2015b. Complementary protein and peptide OFFGEL fractionation for high-throughput proteomic analysis. Analytical chemistry 87, 8481-8488.
  PMID: 26168396


• Zhang, Y., Muller, M., Xu, B., Yoshida, Y., Horlacher, O., Nikitin, F., Garessus, S., Magdeldin, S., Kinoshita, N., Fujinaka, H., Yaoita, E., Hasegawa, M., Lisacek, F., Yamamoto, T., 2015a. Unrestricted modification search reveals lysine methylation as major modification induced by tissue formalin fixation and paraffin embedding. Proteomics 15, 2568-2579.
  PMID: 25825003


• Zhang, Y., Xu, B., Kinoshita, N., Yoshida, Y., Tasaki, M., Fujinaka, H., Magdeldin, S., Yaoita, E., Yamamoto, T., 2015c. Label-free quantitative proteomic analysis reveals strong involvement of complement alternative and terminal pathways in human glomerular sclerotic lesions. Journal of proteomics 123, 89-100.
  PMID: 25835966


• Magdeldin, S., Blaser, R.E., Yamamoto, T., Yates, J.R., 3rd, 2015a. Behavioral and proteomic analysis of stress response in zebrafish (Danio rerio). Journal of proteome research 14, 943-952.
  PMID: 25398274


• Magdeldin, S., Moresco, J.J., Yamamoto, T., Yates, J.R., 3rd, 2014. Off-Line Multidimensional Liquid Chromatography and Auto Sampling Result in Sample Loss in LC/LC-MS/MS. Journal of proteome research 13, 3826-3836.
  PMID: 25040086