Immunostaining (IHC) & fluorescent in-situ hybridization (FISH)
Immunostaining tests are rigorously validated before implementation for clinical diagnosis and is focused on diagnostic, predictive and prognostic protein/markers (antigens).
- VENTANA autostainers (BenchMark ULTRA).
- Over 100 immunostaining diagnostic, prognostic & predictive tests e.g. HER2/neu, C-myc, C-Kit, Ki-67 … etc.
FISH is a unique service based on staff expertise, instrumentation & a comprehensive marker list of tests.
- Available FISH tests for clinical diagnosis:
- CMYC amplification.
- NMYC amplification.
- FOXO rearrangement.
- EWSR rearrangement.
- Synovial sarcoma rearrangement.
- A much more is always added, keep tuned…
| Available Immunostaining Panels | |
| Hematolymphoid | |
| CD20 | CD43 |
| CD163 | CD19 |
| CYCLIND-1 | CD3 |
| CD138 | CD4 |
| CD8 | CD13 |
| CD30 | CD33 |
| CD15 | CD23 |
| CD1A | CD7 |
| CD56 | cmyc |
| CD61 | ALK |
| CD99 | CD31 |
| BCL6 | CD5 |
| BCL2 | CD10 |
| CD79a | EBV |
| TdT | PAX5 |
| CD21 | MPO (MYELOPEROXIDASE) |
| CD3 | CD207 (Langerin) |
| CD34 | GLYCOPHORIN |
| CD68 | CD45LCA |
| MUM-1 | |
| Soft tissue & Bone | |
| BCOR | Calponin |
| Factor VIII | S100 |
| ERG | Desmin |
| DOG-1 | ETV6 |
| SDHB | TFE3 |
| h-caldesmon | NUT-1 |
| SOX10 | STAT-6 |
| ETV4 | MYOGNIN |
| B-Catenin | WTI |
| C-KIT (CD117) | IH SMA |
| EGFR | FACTOR XIIIa |
| NESTIN | INI |
| TLE-1 | FLI-1 |
| NKX-2 | ALK |
| CD99 | EMA |
| Carcinoma work-up | |
| CK | Calcitonin |
| EMA | D2-40 |
| CK7 | GLYPICAN3 |
| CK20 | CK19 |
| CDX-2 | HBME-1 |
| SAT-B2 | HMW CK |
| TTF-1 | HEPPAR-1 |
| Synaptophysin | AFP |
| Chromogranin | P63 |
| Inhibin | CALRETININ |
| THYROGLOBULIN | HMB45 |
| MMR-4 markers | |
| CEA | |
| Breast Cancer Hormonal Panel | |
| ER | HER2-NEU |
| PR | Ki-67 |
| CNS Panel | |
| OLig2 | Inhibin |
| EMA CONC | EMA |
| p53 | Synaptophysin |
| YAP-1 | CK |
| LIN28 | B-catenin |
| GAB-1 | CD117 |
| GFAP | INI |
| Targetable | |
| PDL-1 | |
| FISH Panels | |
| Hematolymphoid Panel | |
| IGH/MYC FUSION (FISH) | BCL6 FUSION (FISH) |
| Aggressive B-cell Lymphoma FUSION pnel (FISH) | BCL lymphoma FUSION Panel (FISH) |
| BCL2 FUSION (FISH) | |
| Soft tissue/pediatric Panel | |
| Ewing Sarcoma FUSION (FISH) | Synovial Sarcoma FUSION (FISH) |
| FOXO FUSION (FISH) | MYCN amplification (FISH) |
| CNS Panel | |
| EGFR CNV (FISH) | C19MC /19p13 (FISH) |
| Other FISH TESTs | |
| NTRK FUSION (FISH) | EGFR (CNV) FISH |
N.B. Targetable, CNS & hematolymphoid FISH panels will be available within 1 month